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HLA Typing for Celiac Disease

$311.00 $189.94
Celiac disease is a multigenic immune-mediated enteropathy triggered by dietary proteins, commonly known as glutens, present in wheat, barley, and rye. Varied clinical manifestations begin either in childhood or adult life. Its prevalence in the united states ranges from 0.5 to 1%. Celiac disease is strongly associated with the HLA genetic region. Approximately 90% of celiac patients express the HLA-DQ2 molecule. Most of the DQ2 negative patients express the HLA-DQ8 molecule. Gluten peptides presented by these HLA molecules induce an abnormal mucosal immune response and tissue damage. The HLA-DQ molecules are heterodimers of an alpha and a beta chain. The beta chain of HLA-DQ2 is coded by HLA-DQB1*02 and of DQ8 by HLA-DQB1*0302. HLA-DQB1 genotyping allows clinicians to evaluate the genetic predisposition for celiac disease in a patient.
  • Tests Included:

  • Est. 7 days Turnaround

  • Specimen type:

HLA-DQ2 (DQA1*05/DQB1*02), HLA-DQ8 (DQA1*03/DQB1*0302), HLA-DQA1*, HLA-DQB1*
  • Test Code: 17135
  • CPT Code: 81382 (x2), 81376 (x2)
  • Alternate Name: N/A
  • Test Instructions : None Required
  • Fasting: No
  • Methodology: Polymerase Chain Reaction Amplification followed by Sequence Specific Oligonucleotide Probes (PCR-SSO)
  • Results In: 7

    Note: Turn around times on results are an estimate and are not guaranteed. The lab may need additional time due to holidays, confirmation/repeat testing, etc. You can contact us to discuss when your results should be ready and we will contact the lab on your behalf immediately.

Determine if someone has Celiacs Disease and to assist in ruling it out
  • Step 1

    Order
    Your Tests

    Doctor’s order provided & Same Day Testing.

  • Step 2

    Go to
    Local Lab

    Your specimen will be collected for you at a local testing center.

  • Step 3

    Get
    Results

    Results sent electronically in 2-3 days* More complex tests take longer.

  • Step 4

    Make
    Better Decisions

    Use your lab results to help make better health decisions. Knowledge is nothing if it isn’t used.

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