Total reviews 411
Total reviews 411
Tests Included: 2
Est. 5-7 (business days) Turnaround
Specimen type: Blood
Quest Diagnostics Location
Nicotinic acid occurs naturally in plants and animals and is also added to many foods as a vitamin supplement.
Tests Included: 2
Est. 5-7 (business days) Turnaround
Specimen type: Blood
Quest Diagnostics Location
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Please do not exercise prior to testing. It is best that your blood is taken in a rested state.
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Nicotinamide
Nicotinamide is a metabolite of nicotinic acid. Due to the large variability in the metabolism of nicotinic acid, plasma concentrations of this metabolite are variable. In one study, fasting plasma concentrations were reported to be approximately 40 ng/mL. In another study it was reported that the administration of a single 1000 mg of an extended-release tablet of nicotinic acid resulted in a mean peak nicotinamide concentration of 400 ng/mL between 5 and 10 hours post-dose, decreasing to about 100 ng/mL by 16 hours post-dose.
Nicotinic Acid
Due to the large variability in the metabolism of nicotinic acid, the dosing preparation used (immediate-release vs. extended-release), and the mg doses used, the serum concentrations may range from less than 20 ng/mL to about 30,000 ng/mL. After oral administration of an immediate-release tablet, peak plasma concentrations occur in 4 to 5 hours. The plasma half-life of nicotinic acid is about one hour. In one study, fasting plasma concentrations were reported to be less than 20 ng/mL. In another study, it was reported that the administration of a single 1000 mg extended-release tablet resulted in mean nicotinic acid concentrations of less than 50 ng/mL.
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